Critical Analysis Essay Example | Topics and Well Written Essays - 750 words - 6

Critical Analysis - Essay Example In this paper, the authors report on the effects of PDNF on tyrosine hydroxylase (TH) activity, a rate-limiting enzyme during the synthesis of dopamine and other catecholamine neurotransmitters. TH is important because it is involved in increasing the production of neurotransmitters. The study came up with the following additional actions of PDNF: Strengths. The paper has many strengths. First, it presented data that was based on solid experimentation that covered a wide range of immunological, molecular, and imaging techniques. The data was clearly presented using graphs and images. The discussion was straightforward and concise. The strongest point of the study is the methodology followed to arrive at the results. The authors arrived at their results through a series of experiments that each showed the action of PDNF on TH. To show that PDNF increased the TH expression in PC12 cells and primary mesencephalic neurons, the authors grew the cells in media that was treated several times with PDNF. Results obtained with immunostains were confirmed using immunoblots. Western blots and SDS-PAGE were also utilized. The study also used a luciferase gene assay to check the effect of PDNF on the promoter of TH. The method used to confirm the mechanism of action of PDNF on TH was done in a simple manner, where a construct of a mutation for the cAMP response element (CRE) labelled with luciferase transfected to PC12 cells. This step was able to show the effect of CRE on the action of PDNF on TH promoter activity. The discussion portion was able to summarize in a clear manner the results of the experiments, and related these to previous work done in the field of TH activation. The paper points to the mechanisms that could explain the action of PDNF. As an example, it was pointed out that PDNF mediated the phosphorylation of serine residues in the catalytic sites of TH. The phosphorylation activity of PDNF was

Report 'Holyhead to Cowes' Essay Example | Topics and Well Written Essays - 2000 words

Report 'Holyhead to Cowes' - Essay Example It is in line with this that the report was prepared to give stakeholders a very vivid idea of the final costing and planning of the event. The report focused on key aspects of the planning that has been done so far and how the event is hoped to be delivered on the due date. Key areas of planning that has been put in place so far include completed work structure, costing structure, health and safety preparations, risk management, and communication plans. Based on these preparations that have been completed, it has been concluded that the university is in a position to successfully start off its race on the planned date. 2.0 Event Management 2.1 Pre-planning The pre-planning focuses on answering the 5W questions (Brenke &Wagner 2006). On the question of why the event is important, it would be noted that this is an event that will serve as a platform for the union to be of relevance to its society through the raising of fund to support society welfare. On the question of what will be p resented at the event, a simple answer of a cycling race will be given. There will be detailed information on where the event will take place but this could be summarised as following a route from Holyhead to Cowes. The event is planned to take place on the 4th of May 2014, in the open lanes of the identified route from 6am to 5pm on each day; and this answers the question of when. Lastly, the question of who is answered by identifying the stakeholders of the event, who include executives of the union, event planners, cyclists and community members 2.4 Event overview Generally, this is an event of fund raising cycle ride that is to take place from Holyhead on Angelsey to Cowes. The event can therefore be said to be made up of two major broad goals, the first of which has to do with the need to have a cycling race in place for selected cyclists. As part of the cycling component of the event, event planners are expected to gather thirty (30) cyclists in good standing who will be engag ed in competitive cycling sport from Holyhead to Cowes. The second component of the event is the fund raising, which requires the event planners to be in a position to put in place structures that will ensure that philanthropists and other donors give to a good course, which is being championed by WUCC. The whole event is scheduled to take place on the 4th of May, 2014. 2.3 Work Structure The structure of the event is expected to have five (5) major divisions or parts, which will be made up of route management, hotel booking, registrations, operations and marketing. The structure is however expected to follow a multi level approach, meaning that each of the major components will have its own sub divisions. For example under the route management, there is expected to be the appointment of team leaders who will further map out the required areas for the race. Under the hotel booking, it is expected that search will also be made for bike

Stevens Johnson Syndrome Essay Example | Topics and Well Written Essays - 500 words

Stevens Johnson Syndrome - Essay Example Recommendations for managing this conditionStevens-Johnson Syndrome is an emergency that needs immediate hospitalization in burn or intensive care units. The initial treatment in managing this condition is based on determining the cause. In this case, the condition is triggered by medication, thus, discontinuation of the medication is recommended (Sooriakumaran et al. 2006). According to Patterson et al. (2009), early discontinuation of the causative drug has been proven to improve survival rate in affected patients (p. 234). As a precaution, all medications ought to be discontinued, to minimize complications. Next, oral lesions are administered mouthwashes. According to McCance & Huether (2014) anesthetics are used in pain control, as the pain is intense (p. 1627). In addition, the patient must be allowed to rehydrate their bodies via intravenous fluid repletion, the ocular surface is lubricated. The patient has to be given a consult by an ophthalmologist because of the eye damage r isk (Wright & Spiegel, 2006). Regions which contain shed skin ought to be covered with compresses of Burow or saline solution and tetanus shots must be administered to the patients. Special attention is given to hemodynamic and airway stability. Nutrition also plays a vital role in managing this condition. Proper management entails supportive care to the patient as the treatment is symptomatic. A vital pointer is that the environment must be hygienic and sterile, to prevent any infection.

Examining Barriers to effective physical health care management of Literature review

Examining Barriers to effective physical health care management of people with schizophrenia - Literature review Example same to different factors such as the association between mental and physical illnesses and the complications resulting from the mental illness itself following persistent use of medication. Schizophrenia patients and other mentally ill patients often suffer many physical health-related problems. Various studies on the interaction between physical health and mental health indicate psychiatric patients often endure physical health complications. In their article, Heggelund et al (2011) posited that most of the patients with Schizophrenia and major depression often suffer from cardiovascular and respiratory disease. The authours attribute the occurrence of these diseases in these patients to higher rates of smoking. In addition, Harrison and Gill (2010) suggest that the people with Schizophrenia experience poor dietary habits, poor living conditions and cognitive impairment among others. Heggelund et al. (2011) observed that patients suffering from Schizophrenia tended to gain weight and become obese. A research conducted by Brown and Mitchel (2012) showed that the incidence of obesity was high in Schizophrenia patients, accounting for up to 42% compared with 27% of the general population. The high percentage of Schizophrenia patients developing obese has thus been a key physical concern largely because it leads to the development of diabetes among other diseases. The tendency by the Schizophrenia patients to become obese has been attributed to different factors. In their article, Connolly and Kelly (2005) suggested that one of such factors is because the patients, in many cases, consume poor diets that are rich in fat and low fibre content without any consideration of the health implication. The authors also argue that these patients tend to lead a sedentary life, and this often reflects symptoms such as apathy and somnolence. The accumulation of calories in their bodies coupled with poor diet and lack of regular exercise serve as the predisposing factors for

Journal for Notorious Essay Example | Topics and Well Written Essays - 1000 words

Journal for Notorious - Essay Example The viewer is waiting for a close-up of the principle character but has to look for the woman in the crowd. It is also necessary to add that Alicia appears as an elegant woman pertaining to the high society. In this case, the director remains ‘faithful’ to this image and the woman appears as the same elegant lady in exquisite gowns throughout the entire movie. When it comes to Devlin, he appears as the ‘mysterious’ Mr. Right. He is sitting in the forefront and only his silhouette is seen. The viewer observes numerous things happening in the room. For instance, the couple is dancing, other people are sitting. It is clear that Alicia is interested in the Mr. Silhouette. The viewers are bound to focus on the mysterious man and wait when his face is seen. It is possible to note that the degree of anticipation is greater when Devlin’s silhouette appears. When it comes to the character’s costumes, he is always elegant and elaborate. 2. The viewer starts caring about the two leading characters when they are on the board of the plane taking them to Rio. Devlin tells the news about Alicia’s father (which is really intimate) and she shares her feelings about her relationships with her father as they used to be. She opens up her heart and it is clear that she is a good person just like Devlin is. It is also clear that the two are destined to be together though this idea comes to the viewers’ mind during the first scenes of the movie when Alicia meets Devlin at the party. 3. Hitchcock sets a romantic and somewhat dramatic tone to the film. There are elements of a comedy but the overall mood is rather dramatic. It is especially vivid in one of the final scenes when Devlin saves Alicia and tells her about his love. There is always a reminder of the war or spy secrets and duty or some plot. More so, the principle female character’s life has been rather tragic and it is not clear whether there will be a happy end for her. She is

Still Life Art Research Paper Example | Topics and Well Written Essays - 1500 words

Still Life Art - Research Paper Example Still life painting is ubiquitous in historic Egyptian tombs. Egyptians are considered one of the oldest civilizations of the world and the existence of still life is an indicative of its historic nature. The concept behind Egyptian still life was that these pieces of art would turn into real life in the afterlife and would be available for use for those who have deceased. The Greek civilization also shows the presence of still life art. Sticking to its own norms and rules, academic reflections tend to lag behind developments in the art world. The word still life was used as late as the 17th century and was first discovered in Dutch inventories (Slive). Other terms which were considered for defining the aforementioned art included fruytagie, bancket and ontbijt. In the 17th century the Parisian Academy of art helped in the foundation of the first schools of art in Europe. A specific set of rules were laid down that explained which forms of art will be taught on a hierarchical basis. Still life was struggling at the bottom of that list because they were considered as mere recordings of inanimate objects or things that were considered to be there without much thought to how they came about in existence. Still life, however, was later acknowledged as a true form of art and gained repute with every additional contribution. Several artists used it as a starting point and often considered the results of still life to be much more appealing than what they thought they would be (Schneider). The earliest forms of most medieval still life were designed in an era that was struck with economic turmoil as well as the dissolution of feudalistic cultures. The motifs of these paintings, hence, were indicative of the changes in economic and social conditions taking place. There were changes in agricultural situations and status quos as well. Some of the art was aimed to depict those changes. Two of the primary scenes depicted in the era were market scenes and kitchen scenes (Eb ert-Schifferer). The 16th Century: The 16th century was the tipping point for still life art as there was an enormous increase in interest in nature and the creation of botanical encyclopedias that informed of the discoveries of the new world and Asia. These areas of interest were subject to significant use by still life artists as their paintings and artistry moved towards their depiction. While the first half of the 16th century did not recognize still life as an autonomous category of art, by the latter half of the century autonomous still life was evolved. Slowly but surely, religious content started to diminish from paintings and artists started to focus more on still objects. The key contributors of still life in the 16th century include Alberceht Durer, Maarten van Heemskerck, Annibe Carraci and Joachim Beuckelear. The 17th Century: The 17th century saw the growth of Italian still life art. Despite its growth, however, it was considered inferior to art that focused on histori cal, religious and mythological subjects. Many prominent contributors and artists thought that still life art was lacking something and had some way to go before any piece of the art could be considered as great. This is one of the reasons why there were considerably lesser number of people who dedicated their work to still life. Some of the prominent artists who contributed to still life include Caravvigo and Jan

Critique on Dead Aid by Dambisa Moyo Essay Example | Topics and Well Written Essays - 2000 words

Critique on Dead Aid by Dambisa Moyo - Essay Example Dambisa Moyo has an exceptional background on the African economy, since she has degrees from prominent learning institutions such as Harvard and Oxford. She has also worked in major organization globally such as World Bank and Goldman Sachs (Collier, 2009). The concept of the book is accepted because it has outstanding information. The summary of the research question of the argument, and theoretical framework of the Dead Aid is aptly analyzed. The internal analysis of Moyo’s book is examined in details by stating the type and eminence of evidence used. Lastly, a discussion on the input of the book to the larger debates on Globalization is discussed aptly. Part 1 Summary of the Research Question of the Argument, and Theoretical Framework of the Book The summary of the research questions of the argument and theoretical framework from Moyo’s Dead Aid is; ‘Is foreign aid affecting African economic progression negatively?’ The basic argument shows whether fore ign aid set for Africa has failed, secondly, whether it has accelerated poverty in the African continent. Finally, it recommends other effectual ways of improving economic development instead of relying on foreign aid. The book discusses whether foreign aid granted to African countries has caused monumental injury, which damages the intended sectors such as political and monetary to be sustained. Part 2 Internal critical evaluation of the book: type of evidence used, quality of the evidence Case selection & how well does the evidence support the argument? The case selection of the book affirms how Moyo states causes and effects of foreign aid in African states. She tries to uncover the real truth to the world, which shows the failure of western countries to put extra efforts in finding other alternatives of making Africa’s economy stable and strong, despite the fact that their intentions of offering the donations are constructive. Thus, Dead Aid argument uncovers the ideologi cal myth of aid as the core reasons for the underdevelopment of African states and the undermining the moral principle that makes granting of foreign aid as a political and ethical imperative. The case selection of the book tries to expose the failures of foreign aid in improving the economic status of Africa by stating the historical ascription of aid (Moyo, 2009). She states various methods western countries used to give out foreign aid as a tactical maneuver throughout the Cold War period. She also states the practical inefficiencies of handling the huge sum of foreign money by leaders in the economically deprived countries. She also blames the defective structure of aid that is implemented by countries, which has failed to bring economical change to African states. In her book, she highlights the growth rates of >5% and the high rankings of African stock exchange as evidences to show how the economy has improved in the states in some instances. These are some of the evidence and strengths of Dead Aid that approves the argument put across. Nonetheless, Moyo emphasizes by stating that Africa will continue to be the same, despite the positive shown and depicted by the progress of economic status. Another issue she brings to light is that individuals from African states will continue to remain in the same poor condition, as long as it receives foreign aid from diverse western counties. She illustrates the current condition in